1,2-rearrangement
ORGANIC REACTION
Whitmore 1,2 shift; 1,2-shift; 1,2-migration
A 1,2-rearrangement or 1,2-migration or 1,2-shift or Whitmore 1,2-shift is an organic reaction where a substituent moves from one atom to another atom in a chemical compound. In a 1,2 shift the movement involves two adjacent atoms but moves over larger distances are possible.